طراحی یک روش آنالیز جدید جهت تعیین مقدار همزمان ترامادول و دو متابولیت اصلی آن o-desmethyltramadol و n-desmethyltramadol در پلاسمای انسان

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منابع مشابه

Postmortem redistribution of tramadol and O-desmethyltramadol.

Tramadol is a widely used analgesic opioid for moderate-to-severe pain due to its efficacy and safety. Although tramadol induces less adverse effects compared with other opioids, an increased number of documented cases of dependence, abuse, intentional overdose or intoxication have been described. In fatal intoxication, the interpretation of the probable cause of death often relies on the measu...

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Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes.

The influence of CYP2D6 genotype and CYP2D6 inhibitors on enantiomeric plasma levels of tramadol and O-desmethyltramadol as well as response to tramadol was investigated. One hundred and seventy-four patients received one hundred intravenous tramadol 3 mg/kg for postoperative analgesia. Blood samples drawn 30, 90, and 180 min after administration were analyzed for plasma concentrations of the e...

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Simultaneous determination of tramadol and O-desmethyltramadol in human plasma using HPLC-DAD.

A sensitive and accurate method for the extraction and quantification of tramadol (T) and its active metabolite, O-desmethyltramadol (ODT) in human plasma with high-performance liquid chromatography-diode array detection was developed and validated. The analytes were extracted from plasma samples by tert-butylmethyl ether in the presence of ammonium hydroxide as alkaline medium and back extract...

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Evaluation of Analgesic Efficacy and Associated Plasma Concentration of Tramadol and O-desmethyltramadol Following Oral Administration Post Ovariohysterectomy

Tramadol is used in both human and veterinary medicine to treat postoperative pain. In human subjects, variation in metabolism of tramadol has led to inconsistent analgesia in some individuals. The purpose of the current study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol was randomly as...

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Degenerate Four Wave Mixing in Photonic Crystal Fibers

In this study, Four Wave Mixing (FWM) characteristics in photonic crystal fibers are investigated. The effect of channel spacing, phase mismatching, and fiber length on FWM efficiency have been studied. The variation of idler frequency which obtained by this technique with pumping and signal wavelengths has been discussed. The effect of fiber dispersion has been taken into account; we obtain th...

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وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی تهران - دانشکده داروسازی

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